Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis
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Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring
Exogenous addition of neutralising antibody to transforming growth factor-β1,2 to cutaneous wounds in adult rodents reduces scarring. Three isoforms of transforming growth factor-β (1, 2 and 3) have been identified in mammals. We investigated the isoform/isoforms of TGF-β responsible for cutaneous scarring by: (i) reducing specific endogenous TGF-β isoforms by exogenous injection of isoform spe...
متن کاملDiverse cellular TGF-β1 and TGF-β3 gene expression in normal human and murine lung
Diverse cellular TGF-β1 and TGF-β3 gene expression in normal human and murine lung. R.K. Coker, G.J. Laurent, S. Shahzeidi, N.A. Hernández-Rodríguez, P. Pantelidis, R.M. du Bois, P.K. Jeffery, R.J. McAnulty. ERS Journals Ltd 1996. ABSTRACT: A role for transforming growth factor-beta1 (TGF-β1) has been proposed in lung development and in the pathogenesis of pulmonary disease. However, previous ...
متن کاملExpression of TGF-β3 in Isolated Fibroblasts from Foreskin
Background: The multifunctional transforming growth factor beta (TGF-β) is a glycoprotein that exists in three isoforms. TGF-β3 expression increases in fetal wound healing and reduces fibronectin and collagen I and III deposition, and also improves the architecture of the neodermis which is a combination of blood vessels and connective tissue during wound healing. Fibroblasts are key ...
متن کاملTGF-Β1 Transduced Mesenchymal Stem Cells Have Profound Modulatory Effects on DCs and T Cells
Background: Mesenchymal stem cells (MSCs) and transforming growth factor-β1 (TGF-β1) molecules are well known for their immunomodulatory properties and their function in tissue regeneration and remodeling. Objectives: To evaluate the interaction of TGF-β1 engineered MSCs with T cells and dendritic cells (DCs) and their modulatory effect on the immune response. Methods: MSCs and DCs were generat...
متن کاملThe Expression Level of TGF-β1, TGF-β3 and VEGF in Transplanted Oral Mucosal and Cutaneous Wounds
Oral mucosal wounds heal faster with minimal scar compared with cutaneous wounds. In order to reduce the effect of environmental factors and find the expression difference of growth factors in oral and dermal wound, this study created the following rat wound model. The oral mucosa was firstly transplanted to left abdominal skin and after the wounds healed, a line-like full-thickness excisional ...
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ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2015
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2014.12.007